PHGY 312 Lecture Notes - Lecture 9: Ascending Limb Of Loop Of Henle, Aquaporin 1, Aquaporin 2
24 May 2016
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Document Summary
In pt, water reabsorption is passive, 67% of filtrate is reabsorbed. In loop of henle, water reabsorption occurs in descending thin limb only. In dt, there"s no water reabsorption, 0% of filtrate is reabsorbed. In late dt and ccd, water reabsorption is passive and mediated by avp, anp, Tetramer of subunits, each with 6 membrane spanning segments. Aqp1 = located in pt on apical/basolateral side. Aqp2 = located in ccd on apical side, is responsive to adh. Pt is highly permeable to h2o due to aqp1 in apical/baso membrane. Increased hydrostatic pressure due to paracellular absorption: forces fluid and. Excretion of urine of variable osmolality via avp (adh) by changing amount of. Occurs at: thick ascending limb of loop of henle. Nephron reabsorbs solute without letting water through the epithelium. Descending limb and ascending limb (more solute reabsorption) Distal tubule and collecting tubule tubular fluid (absence of avp) Hyperosmotic compartment to reabsorb the water through passive osmosis.
