PHGY 312 Lecture Notes - Lecture 10: Nucleoprotein, Uric Acid, Alkalosis
24 May 2016
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Most buffering molecules show a sigmoid relationship with half maximal point at. Most of energy comes from metabolism of carbs. Most of co2 generated can be blown off in the lungs when we make volatile acids. Each day the body is producing acid causes an elevation in co2 increases the pka o ventilation rate o. Patients with renal failure will show a decrease in ph because kidney maintains the ph despite constant addition of acid (prevents this decline) 3 types of reactions that give rise to endogenous acid: oxidation of organic s to so4. 2- + 2h: conversion of neutral foodstuffs to organic acids o o o. Metabolism of glucose citrate + 3 h+ or 2 lactate + 2 h+ Metabolism of nucleoprotein urate + 2 h: hydrolysis of phosphoesters o. Hco3- works as a buffer through 2 reactions: hydration: co2+ h2o h2co3. Slow, requires carbonic anhydrase: dissociation into bicarbonate: h2co3 hco3- + h+
