PHGY 312 Lecture Notes - Lecture 12: Body Water, Phenazone, Thiocyanate
24 May 2016
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Phgy 312-lecture 12: control of body water and sodium balance. Output = urine, feces, skin/sweat, exhaled air: insensible losses=skin losses and respiratory surfaces. Total body water is around 60% (icf is 2/3, and ecf is 1/3) Ecf is composed of transcellular, plasma, interstitial fluid, and dense connective tissue/bone. There is little exchange between dense connective tissue/bone and transcellular water and plasma. Estimating volume of a compartment using dilution of a marker. Ecf markers: inulin/sucrose/mannitol (main ones, sulfate, bromide, radio chloride and sodium, thiocyanate. Total body water markers: deuterium oxide (d2o, tritium oxide, antipyrine, desiccation. Icf content is obtained by subtracting ecf from total body water. Elution = introduce solute of known amount wait for =bm measure final concentration: you can determine the volume of the compartment via, v=q/c. Forces moving fluid out: (decreases from arteriole to vein: capillary hydrostatic pressure, isf oncotic pressure, negative free isf pressure. Forces moving fluid in: (increases from arteriole to vein: plasma oncotic pressure.
