PHGY 313 Lecture Notes - Lactulose, Laxative, External Anal Sphincter
17 Jul 2013
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Document Summary
Symptoms: infants pass very little meconium and distended abdomen. Surgery must be done to remove the distal large bowel to cure the condition. This is a congenital disease that is associates with down"s syndrome and chromosomal deletions. There is a loss of intramural ganglion cells (excitatory and inhibitory) in the myenteric and submucosal plexi. The lumen is made of smooth muscle so it is tonically contracted and narrow, obstructing the flow of feces. There is a build up of matter behind it, distending the proximal colon (creating a megacolon). Expand on the innervation of the intestine and the function of the enteric nervous system. The biopsy reveals an absence of ganglion cells to the area of the colon. An elevated level of acetylcholinesterase also indicates an abnormality of the cholinergic innervation. Intrinsic inervation: ach, cp (+), vip, no (-) Extrinsic innervation is by both sympathetic (+,-) and parasympathetic (+).
