PHGY 313 Lecture Notes - Lecture 1: Lateral Hypothalamus, Leptin Receptor, Ventromedial Nucleus Of The Hypothalamus
24 May 2016
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Document Summary
Phgy 313: regulation of energy homeostasis-hypothalamic control of food intake. Energy balance is centrally regulated: o o o o o. Observations: (arc) o o o blood o o o o o. 3rd ventricle (3v), dorsal and ventromedial nucleus (dmn and vmn), arcuate nucleus. Profound obesity from destruction of hypothalamic: paraventricular nucleus, pvn, ventromedial nucleus, vmn, dorsomedial nucleus, dmn. Anorexia/weightloss from destruction of lateral hypothalamic area (lha) Parabiosis = surgical union of 2 individuals, so that they share a common circulation of. Interpretation: circulating factor involved in energy balance regulation, defects in ob/ob and db/db bay be in signal and the receptor for that signal, respectively. Signals to the brain the state of energy stores in peripheral tissues. Leptin restores normal body mass in leptin deficient patient. Cell-surface leptin receptor (lepr), member of type 1 cytokine receptor family. Leptin receptor is expressed in several areas of hypothalamus. Npy/agrp = increase food intake, pomc = decrease food intake.
