PHGY 313 Lecture Notes - Lecture 13: Antigen-Presenting Cell, Lectin, Complement Component 5A
24 May 2016
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Phgy 313-lect 13: innate immunity2: complement and antigen presenting cells (apcs) Made up of a variety of plasma proteins that interact with one another; proteases. 4 main effects: clearance of immune complexes (neutralize ab-antigen complexes, opsonization, activation of inflammatory response (promotes extravasation, lysis. Important for ec pathogen elimination, also linked to antibody activity. 3 pathways for recognition and response o o o o o: classical. Effector functions: peptide mediators of inflammation, phagocyte recruitment: lectin. Recognizes: mannose-binding lectin or ficolin binds carbohydrates on pathogen surface o o o complexes. Complement o o o o o o o o o o o o o o. Binds to complement receptors on phagocytes, opsonization, removal of immune: alternative. Effector functions: mac, lysis of certain pathogens and cells. C3 convertase regulates downstream mediators of complement system. C3b = key tag, gets deposited on bacteria surface, leading to opsonization. Spontaneous cleavage of c3 and binding of c3b fragment of pathogen surface.
