PHGY 314 Lecture 35: PHGY314 Schmuel 3 RSN at mesoscopic scale
8 Dec 2016
School
Department
Course
Professor
Document Summary
Overview of brain from macro to micro scale: Cns systems maps circuits neurons synapses molecules. Large scale networks cortical areas cortical columns. Meso: connections within/btwn cortical columns, or local cell assemblies. Macro: anatomically segregated brain regions: based on slow-fluctuations in bold signal in fmri, partly reflect fluctuations in neurophgy activity (what we did last 2 lecs, defined according to similarity of time-courses of slow-fluctuations in. Nirs = near-infrared optical imaging: various ways to image the human brain, can also observe those fluctuations. Micro: single neurons and synaptic connections conventional fmri voxel is 2x2x2mm, samples at 1 volume at 1-2s. Bold signal is sluggish and lags (peaks at 5-6s) So fmri misses high-res info at meso scale. Very fast, so can image single neuron or large popl of neurons" firing activity at ms time resolution scale. Linearity between vsd fluorescence levels and firing rates. Experiment: measured intracellular recording and optical vsd recordings, overlayed them.
