PHGY 314 Lecture 33: PHGY314 Schmuel 1 neuro measurement techniques
8 Dec 2016
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Bold functional-mri signals and the underlying neurophysiological activity. Schmuel 1: fmri bold hemodynamic signal vs neurophysiological signals. All other sections described brain during active processes: when no task pursued, is brain activity random, is spontaneous activity related to tasks or stimuli responses. Cortical columns and cortical layers can be distinguished fmri gets overall activity of neurons in a voxel, so it"s 3d. Standard: 3-tesla field potential in the mri: the voxel is about 2x2x2mm, so each voxel gets 10^6 neuron somas, 10^10 synapses. Method of usage: give patient a stimuli (ex. Something to look at: collect brain waves . Works based on neurovascular coupling: neuronal activity change in cbf mri/pet/oi (oi is used for humans and animals) measurement detects cbf changes. Intracellular electrodes: measure transmembrane electrical events, not very common: record a lil downstream, can"t do invivo, need to do in vitro on a slide. We can measure that reverse current outside the cell.
