PHGY 314 Lecture 34: PHGY314 Schmuel 2 Resting State Networks
8 Dec 2016
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Estimating neuronal activity based on hemodynamic activity: its important to learn transformation btwn fmri and neurophysiological activity. Recorded fmri in area v1 in monkeys, monkeys were presented with luminance contrast visual gratings. Normalize fmri and ap spike measures to see them together. Can we say bold (fmri) represents ap because they are linearly the same on the graph: linearity = follows/tracks the same line on the graph, we can say that they are corresponding and proportional but not representative. Measured cerebellar bf with a ldf probe measurement device: 3 electrodes: Record ap of purkinje cells: looked at how lfp relates to cbf, we get a monotonous increasing relationship, but it"s more sigmoidal than linear in parallel fibre stimulation, non-linearities btwn hemodynamic +neurophgy activity have been observed too. Ap and synaptic activity correlate with bold response linearly, which one actually causes. So to find out, dissociate ap and synaptic activity, run tests: Middle: cerebellar blood flow curve (hemodynamic activity)
