PHGY 314 Lecture 37: PHGY314 Sharif 2 dorsal horn circuits
8 Dec 2016
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Document Summary
Dorsal horn of spinal cord"s interneurons/info processing. T1-t12 in humans, t1-t13 in rats. system to selectively express something in certain populations of cells same idea as cre-lox, but can selectively activate certain cells using designer drugs a designer drug to be used in dreadd cells. Nep: adeno-associated virus sciatic nerve injury peripheral nerve injury inhibitory interneuron excitatory interneuron neuropathic pain. Case study: teacher who fell into a manhole. 2 yrs after surgery, she continues to feel pain 8-10/10 pain score. Reported pain at 0/10 at next visit to doctor cord. We still don"t know how scs works though we just know it works. Pain gate theory (lorne mendell"s theory that allowed for the design of scs) has. Flaws: sg neuron doesn"t really exist, we haven"t found it in lamina 1/2, a-betas don"t directly synapse onto projection neurons. Hypotheses on mechanisms of scs via spinal cord circuit.
