PHGY 425 Lecture Notes - Lecture 11: Saccade, Sine Wave, Confidence Interval
23 Jan 2018
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Document Summary
A neuron is said to burst when it fires two or more action potentials followed by a period of quiescence. Slightly vague definition, but more all-encompassing than others: definition of bursting depends on how you quantify it. Sodium channel encased in the lipid bilayer: 4 domains (tetramer), each with 6 transmembrane segments (s1-s6, pore is located between s5 and s6, voltage dependency modulated via s4 (many positively charged residues) We can discuss activation and inactivation kinetics for all of these. This is what we need to generate an ap - interplay between na channel and (at least) a delayed-rectifier. This is the minimum complement of channels required to have the ability to fire an ap. Note: refractory period is set by the time na channels need to recover from inactivation. Hodgkin-huxley = model an ion channel as a voltage-dependent conductance.
