PHGY 502 Lecture Notes - Lecture 10: Steroid Hormone Receptor, Pcaf, Progestin

• School: McGill University
• Department: Physiology
• Course: PHGY 502
• Professor: Simon Rousseau

Document Summary

Small steroid hormone on the top left interacts with the other steroid hormone receptor. When this interaction is messed up, you get diseases like prostrate cancer. Another disease- developmental sex disorder- xy males develop female symptoms. Chrousos- a defect in the signal between the hypothalamaus and the adrenal gland during the production of glucocorticoids- androgen hormones and cortisone are overproduced- increased masculinity. Part 2 - hormone related diseases: androgen insensitivity and particular disorders of sex development, spinal bulbar muscular atrophy, polycystic ovarian syndrome, chrousos syndrome. Part 3 - androgen receptor and prostate cancer. Be able to describe the basic structure/function domains of steroid hormone receptors and how to measure their function. Explain the molecular basis of diseases/syndromes caused by genetic changes in: androgen receptor (ar, glucocorticoid receptor (gr, mineralocorticoid receptor (mr, estrogen receptor (er) Understand the enzymatic pathways involved in steroid hormone biosynthesis: be able to associate mutations in these enzymes with particular disorders of sex development (dsd)