PHGY 210 Lecture Notes - Cotransporter, Natriuresis, Zona Glomerulosa

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Sodium (na) and water are important components of the body fluids. Total-body balance of na and water has to be maintained to sustain normal blood pressure and life. We are in water and sodium balance! water intake = water output sodium intake = sodium output. Depending on intake: water output can vary from 0. 4 l/day to 25 l/day; sodium chloride output can vary from 0. 05 g/day to 25 g/day. Both sodium and water are freely filtered but ~99% is reabsorbed (no secretion). The majority of sodium and water reabsorption (~2/3) occurs in the proximal tubule. Active na+/k+-atpase pumps transport sodium out of the cells and keep the intracellular concentration of sodium low. Sodium moves downhill from the tubular lumen into the tubular epithelial cells. Each tubular segment has different mechanisms. e. g. in the proximal tubule: na+-h+ antiporter. In the ccd: diffusion via na+ channel (counterporter) Plasma concentration of sodium is not a marker for total body sodium.

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