PHGY 311 Lecture Notes - Lecture 3: Posterior Pituitary, Autocrine Signalling, Apposition
13 Dec 2012
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Mechanism that underlie the change in the firing pattern of the ot neurons that lead to burst in ap for milk ejection. Summation: more pups suckling= the more activation of the ot neuron and the higher the freq offirnig and a shorter interval between the burst. Synchronyzation: invloes a plastic change were astrocytes withdraw there processes allowing an increase in the neuronal apposition thus increase in the amount of glutamate that stay etc(slide8) Transition from regular firing to burst of activity. Need a threshold level for activation to cause this transition. Initially was unclear how the continuous suckling led to transition, bc would think that neuron would be bursting all the time. Small slice there all the necessary components to have this transition from regular firing to bursting. Increase in the slope of dep that precedes the ap + a broadening of the ap. All this could happen in a male rat if given the right cond.
