PSYC 211 Lecture Notes - Lecture 8: Autoreceptor, Indirect Agonist, Reuptake
16 Mar 2017
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Catechol amines synthesize with single amino acid: dopamine (da, norepinephrine (ne) adrenaline, epinephrine adrenaline. Idol amines: serotonin (5-ht) synthesized with more than one amino acid. Competitive binding drug molecules compete for the same binding site as the neurotransmitter. These drugs can be an: agonist drug that facilitates postsynaptic transmission, antagonist drug that blocks or inhibits postsynaptic transmission. A direct agonist drug will attach itself to the binding where the neurotransmitter would normally open. 15 the ions pass through and causing a postsynaptic potential. A direct antagonist (receptor blocker) can also occupy the binding site therefore preventing the opening of the ion channel. Non-competitive binding some receptors have multiple binding sites the neurotransmitter binds with one site while the drugs bind with another. An indirect agonist binds with an alternative binding site and facilitates the opening of the ion channel. An indirect antagonist binds with an alternative binding site and prevents the channel from opening.
