ANTHROP 1AA3 Lecture Notes - Lecture 7: Retinitis Pigmentosa, Mutation, Molecular Machine
2 May 2016
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Introns = remove (in eukaryotic genes they tend to be much longer) Mrna that is process is a representation of the whole gene that was transcribed (exons & introns included) The processing creates the 5" cap and the 3" poly(a) tail but also removes the introns and splices the exons together. Proteins hold the pieces in the right place and pull the exons toward each other to create the bubble of the intron. It"s crucial to break the intron-exon boundary precisely at the right spots. Left side of intron is called the 5" end. 5" splice site = gt (gu in rna) ^these fall in the boundaries of the intron (so they are removed) The a residue (adenine) is required for formation for the lariat structure. Proteins and rnas make up the spliceosome: it"s a large molecular machine precursor mrna, the mrna is shown in picture 2 attaching to.
