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UTSGCSB329H1Maurice RinguetteSummer

CSB329H1 Study Guide - Comprehensive Final Exam Guide - Stem Cell, Cell Potency, Gene

OC59619966 Page
20 Nov 2018
0
Lecture 1(a): introduction to stem cells: potency is the number of possible fates available to a cell, potent = having the power to achieve a certain f
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Study Guide - Comprehensive Final Exam Guide - Gene, Dna, Messenger Rna

OC59619991 Page
20 Nov 2018
0
Probes are hybridized to fixed cells or tissues. Also works if we denature chromosomes and add a large amount of the. Dna probe which will eventually b
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UTSGCSB332H1William JuWinter

CSB332H1 Study Guide - Comprehensive Final Exam Guide - Neuron, Wireless Access Point, Protein

OC59619990 Page
19 Nov 2018
0
Cumulative effects of stress: acutely (hours), low to moderate physiological levels of adrenal steroids enhance synaptic function and certain types of
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UTSGCSB329H1Maurice RinguetteSummer

CSB329H1 Study Guide - Summer 2018, Comprehensive Midterm Notes - Stem Cell, Cell Potency, Gene

OC59619966 Page
12 Oct 2018
0
Lecture 1(a): introduction to stem cells: potency is the number of possible fates available to a cell, potent = having the power to achieve a certain f
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UTSGCSB332H1William JuWinter

CSB332H1 Study Guide - Winter 2018, Comprehensive Midterm Notes - Neuron, Wireless Access Point, Protein

OC59619990 Page
12 Oct 2018
0
Cumulative effects of stress: acutely (hours), low to moderate physiological levels of adrenal steroids enhance synaptic function and certain types of
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Study Guide - Spring 2018, Comprehensive Midterm Notes - Gene, Dna, Messenger Rna

OC59619991 Page
12 Oct 2018
0
What is in the (human) genome: build 35: 2. 85 gigabases, 10-5 error rate (1 in 100,000 is incorrect, build 35 = 35th time people tried to put the piec
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UTSGBIO230H1Christopher M Yip

BIO230H1 Lecture Notes - Lecture 1: Endoplasmic Reticulum, Endosome, Exocytosis

OC5961998 Page
16 May 2018
0
Why is membrane trafficking important: cells must engage with other cells, communicate with other cells, acquire resources. Referring to the diagram: a
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UTSGBIO230H1Christopher M Yip

BIO230H1 Lecture Notes - Lecture 2: Tubulin, Centrosome, Microtubule

OC5961996 Page
16 May 2018
0
Inherently polarized have different ends: each protofilament is made of heterodimers of the monomeric proteins (alpha and beta tubulin, tubulin monomer
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UTSGBIO230H1Christopher M Yip

BIO230H1 Lecture Notes - Lecture 4: Guanylyl Cyclase, Nitric Oxide Synthase, Cyclic Guanosine Monophosphate

OC5961997 Page
16 May 2018
0
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UTSGBIO230H1Christopher M Yip

BIO230H1 Lecture Notes - Lecture 4: Signal Transduction, Scaffold Protein, Isogamy

OC5961998 Page
16 May 2018
0
Cellular signaling: cells must communicate to develop and maintain multicellular organisms, unicellular bacterial-like organisms existed on earth for ~
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UTSGBIO230H1Christopher M Yip

BIO230H1 Lecture Notes - Lecture 5: Receptor Tyrosine Kinase, Sh2 Domain, Histidine Kinase

OC5961996 Page
16 May 2018
0
Signaling via protein modifications: enzyme coupled receptors (and protein phosphorylation, use of proteolysis in signaling. Enzyme coupled receptors (
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UTSGBIO230H1Christopher M Yip

BIO230H1 Lecture Notes - Lecture 5: Cyclin A, Cyclin E, Cell Growth

OC5961996 Page
16 May 2018
0
Cell cycle: interphase, g1 phase, cell growth and partially doubling proteins and organelles, s phase, dna replication, g2 phase, cell growth and remai
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 15: Somatic Cell Nuclear Transfer, Cre Recombinase, Open Reading Frame

OC5961992 Page
14 May 2018
0
Gfp expression: created two transgenic lines of mice which were then crossed with each other: , omp promotor driving the expression of cre recombinase,
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 15: Somatic Cell Nuclear Transfer, Bisulfite Sequencing, Transposase

OC5961992 Page
14 May 2018
0
Experiment: retroviral transfection system was used to introduce the 4 required gene into the fibroblast, construct: stem-cell specific promotor (fbx15
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 11: Antisense Rna, Small Interfering Rna, Piwi

OC5961992 Page
14 May 2018
0
Rna interference (rnai): antisense-inhibition, injecting single-stranded antisense rna to hybridize with the target mrna and silence its effects (mild
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture 14: Section 2- L14b

OC5961993 Page
14 May 2018
0
Somatic (fibroblast) cells + embryonic stem cells: generated a cell fusion via chemical treatment with: fibroblast cell (dj1) and escs, hybrid cells we
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 13: Iron Response Element, Upstream Open Reading Frame, Ferritin

OC5961992 Page
14 May 2018
0
Translational control sites: 3" and 5" utr both play an important role in translational control. Iron homeostasis: two different proteins that play imp
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 13: Myristoylation, Palmitoylation, Signal Peptide

OC5961993 Page
14 May 2018
0
Lecture 13(b): translational & post-translational regulation: chaperone proteins interact with the translated amino-acid sequence while the ribosome is
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 10: Cleavage And Polyadenylation Specificity Factor, Flight Instructor, Consensus Sequence

OC5961993 Page
14 May 2018
0
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 9: Fibroblast Growth Factor Receptor 2, Reading Frame, Exon

OC5961992 Page
14 May 2018
0
Lecture 9(c): rna splicing: polyprymidine tract binding (ptb) proteins are a class of proteins related to hnrnps, ptb proteins associate with pre-mrna
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 14: Embryonic Stem Cell, Neural Cell Adhesion Molecule, Cell Adhesion Molecule

OC5961992 Page
14 May 2018
0
Early mammalian development: zygote undergoes cellular division to generate a blastocyst, blastocyst has an inner cell mass: consists of pluripotent em
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 12: Piwi, P Element, Transposable Element

OC5961992 Page
14 May 2018
0
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 11: Locked Nucleic Acid, Rna Virus, Microrna

OC5961992 Page
14 May 2018
0
Triggering rnai: rnai can be triggered by various sources of rna molecules: Lecture 11(b): mirna, rnai & ncrna: endogenous mirnas, exogenous constructs
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture 12: Section 2- L12b

OC5961992 Page
14 May 2018
0
Lncrna h19 & igf2 mirna sponge, lncrna is maternally expressed | igf2 is paternally expressed. Lecture 12(b): pirnas & lncrnas: imp1 is a gene that neg
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 6: Methylated Dna Immunoprecipitation, Bisulfite Sequencing, Demethylation

OC5961992 Page
14 May 2018
0
Lecture 6(b): dna methylation: bisulfite sequencing is the most common method for detecting dna methylation. All upa will become apt: complementary str
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 7: Embryonic Stem Cell, Demethylation, Oct-4

OC5961992 Page
14 May 2018
0
Dna methylation & development: dynamic regulation of methylation is crucial during early development is accomplished by de novo methyltransferases (dnm
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 7: Yeast Artificial Chromosome, Olfactory Receptor Neuron, Olfactory Receptor

OC5961992 Page
14 May 2018
0
Question after formation of the blastocyst, we have a re-methylation event; how can some genes escape this methylation (i. e. housekeeping genes) Dna m
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 6: Small Interfering Rna, Cpg Oligodeoxynucleotide, Myc

OC5961992 Page
14 May 2018
0
Recruiting dnmt3 proteins de novo methylation: recognition motifs: Lecture 6(c): dna methylation: dna methyltransferases may have recognition motifs th
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 9: Exon Skipping, Polypyrimidine Tract, Spliceosome

OC5961992 Page
14 May 2018
0
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 9: Alternative Splicing, Exon Skipping, Transesterification

OC5961992 Page
14 May 2018
0
Lecture 9(b): rna splicing: pre-mrna splicing catalyzed by assembly of snrnps begins with, u1 snrna binds to the 5" splice site, u2af and bbp bind to t
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 8: Non-Coding Rna, Dicer, Heterochromatin

OC5961992 Page
14 May 2018
0
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 7: Genomic Imprinting, Non-Coding Rna, Insulin-Like Growth Factor 2

OC5961992 Page
14 May 2018
0
Ctcf protein functions to prevent heterochromatin from spreading into the escaped region. Genomic imprinting: some autosomal genes are epigenetically r
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 8: Xist (Gene), X-Inactivation, Zygosity

OC5961992 Page
14 May 2018
0
Lecture 8(c): heterochromatin & positioning effect: mommed1 mutation was mapped and found in the smchd1 locus, mommed1 wt: cytosine (c, mommed1 homozyg
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 8: Variegation, Heterochromatin, Euchromatin

OC5961992 Page
14 May 2018
0
Genomic insulators is a dna sequence: ctcf protein is capable of binding to the insulator that functions to block the active and inactive domain from i
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 5: Transferase, Transcription Factor Ii H, Radioactive Tracer

OC5961992 Page
14 May 2018
0
Lecture 5(b): transcription iii: consists of 25-30 separate subunit proteins, mediator complex is not required for initiating transcription in vitro, h
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 3: Histone Acetyltransferase, Histone Deacetylase, Histone Methyltransferase

OC5961992 Page
14 May 2018
0
Chromatin remodeling: two classes of enzymes function in remodeling the chromatin, class i. Covalent modification of histone proteins: modifications in
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 4: Dna-Binding Domain, Leucine Zipper, Zinc Finger

OC5961992 Page
14 May 2018
0
Lecture 4(b): transcription ii: proteins that recognize specific sequences within the gene (i. e. tata box) and function to activate or repress transcr
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 6: Cpg Site, Gene Silencing, Dnmt3B

OC5961992 Page
14 May 2018
0
Chromatin & gene silencing: heterochromatin, condensed chromatin associated with gene silencing, euchromatin, uncondensed chromatin associated with act
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 5: Small Nuclear Rna, Transcription Preinitiation Complex, Tata Box

OC5961992 Page
14 May 2018
0
Multi-subunit mediator complex: general tf work with rnapii vary completely with sequence specific tf. Sequence specific tf => regulating transcription
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UTSGCSB349H1Alan Moses Wolfgang MoederSpring

CSB349H1 Lecture Notes - Lecture 3: H2Afz, Histone Code, Transcription Preinitiation Complex

OC5961992 Page
14 May 2018
0
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