ANTHROP 2U03 Lecture Notes - Lecture 7: Reassortment, Antigenic Shift, 1918 Flu Pandemic

• School: McMaster University
• Department: Anthropology
• Course: ANTHROP 2U03
• Professor: Hendrik Poinar

Document Summary

Group of segmented negative-sense rna viruses with genomes in the (cid:1005)(cid:1006) k(cid:271) (cid:894)that"s. Three types of influenza a, b and c. Influenza a it is the nasty one. Influenza a (common, yearly epidemics, often high mortality, rapid antigenic evolution), pandemic strains. Influenza b and c ordinary flu (less common, low mortality, slower antigenic evolution) All strains change constantly via small mutations. 8 strands of rna, each with 1 gene. Two surgance antigens: hemagglutinin (h), neuraminidase (n) Strains named by combination of surface antigens: h1n1, h2n3. Influenza continues to cause considerable morbidity and mortality each year (~ 36,000 deaths per year in the us) ~ 500,000 influenza deaths globally on an annual basis (although this evidence is unverified) Why do you get the flu every year? (cid:894)or almost(cid:895) . Antigenic drift: minor genetic changes (a, b and c) Antigenic shift: major genetic change (reassortment, a only, a(cid:272)(cid:395)ui(cid:396)es ge(cid:374)es f(cid:396)o(cid:373) othe(cid:396) st(cid:396)ai(cid:374)s of flu: (cid:862)(cid:396)e(cid:272)o(cid:373)(cid:271)i(cid:374)atio(cid:374) o(cid:396) (cid:448)i(cid:396)al se(cid:454)(cid:863)