BIOLOGY 2B03 Lecture Notes - Lecture 2: Alpha Helix, Histidine, Beta Sheet
17 Sep 2013
School
Department
Course
Professor
Document Summary
In class lecture 2 - september 16th 2013. 1980s: studying initial symptoms like memory loss, unaware of your surroundings, feeling like your sleep waking. These diseases are fatal because of pneumonia, and the ability to respond to it. Prion: infectious protein taht exits in two conformations, we already have one of them in our body. The same protein in different shape is fatal. Left: prpc: found in our bodies in some of our cells. The infectious prion is on the right, the sc form. Differences in the two structures: right has more beta sheets, and left has more helices. This protein when its the left shape is good, but when its in the right shape is bad. Protein folding takes awhile, its always folding and unfolding until it gets to the most stable native conformation - which has the lowest energy. Will take many intermediate conformations before the final structure.
