BIOLOGY 2C03 Lecture Notes - Cyclic Adenosine Monophosphate, Glial Cell Line-Derived Neurotrophic Factor, Mechanosensation
28 Jan 2013
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Document Summary
Pain ii: there are many types of noxious stimuli. Pain can be caused by mechanical, chemical, thermal, or electrical stimuli. Basic pathway is drg synapses in dorsal horn to 2nd order neuron, which projects to thalamus via stt, where it synapses to 3rd order neuron to cortex. Endogenous chemical stimuli include ph, atp, k, histamine, and inflammatory products. There are exogenous compounds that can also cause pain. Nsaids mediate their affects by inhibiting cycloxygenase (part of prost. pathway) Cox i is expr in a wide variety of tissues, including gut, mediates gi protection. Cox ii has restricted expr, excluding gut, and mediates inflammation. Cox ii selective drugs ought to be anti-inflammatory w/o irritating gut. Cox iii mediates cns effects on pain and fever. Some c fibers release cgrp and substance p, causes neurogenic inflammation and further pain stimulation (positive feedback) Transduction of stimulus to action potential relies on ionotropic and metabotropic receptors.
