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Lecture

FATTY ACID SYNTHESIS

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Department
Biology
Course
BIOLOGY 2D03
Professor
Laura Parker
Semester
Fall

Description
FATTY ACID SYNTHESIS Use - membranes - energy storage - protein modifications (localization/function) - signaling molecule precursors Where: - fat (storage) - liver (export for storage elsewhere) ACC: makes malonyl CoA biotin carboxylase: adds CO2 to biotin; uses ATP transcarboxylase: transfers C02 to acetyl CoA FA SYNTHASE: 1. ACYL TRANSFER acetyl CoA to condensing enzyme (CE) malonyl CoA to acyl carrier protein (ACP) 2. CONDENSATION malonyl decarboxylation acetyl attacks decarboxylated malonyl CE site free 3. REDUCTION reduce ketone to alcohol (oxidize NADPH) dehydrate reduce double bond (oxidize NADPH) 4. TRANSFER new chain from ACP to CE after 16 carbons, palmityl THIOESTERASE frees from complex B Oxidation vs. FA synth. matrix cytosol NADH/FADH generation NADPH consumption CoA carries acyl groups ACP carrier Origin of cytosolic Acetyl-CoA: pyruvate from glycolysis enters mitochondria, converted to acetyl CoA acetyl coA condenses with OAA to make citrate citrate exported from liver mitochondria b/c ICDH inhibited  NO TCA!! CITRATE LYASE: citrate  OAA + Acetyl CoA NADPH: - malate reduced, decarbed to pyruvate in cytosol  NADPH produced - pentose phosphate pathway REGULATION: - Citrate Transporter inhibited by FFA’s - ACC acetyl CoA activates (feed-forward) citrate activates (fee
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