BIOLOGY 3UU3 Lecture Notes - Lecture 5: Nitrogen Balance, Leptin Receptor, Urocortin
12 Apr 2017
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Document Summary
Power of higher-order cognitive aspects to strongly alter feeding habits: if your eyes are larger than your stomach, your stomach adjusts, ultimate regulation of food intake is how much food your mom gives you. Anorexia nervosa: cognitive/social aspect related to feeding or regurgitation: regurgitation: adaptation of species prone to eating contaminated food. Dogs readily vomits but horses/rats cannot (generally vegetarian lower chance of being exposed to toxins) Rats: risk aversive neophobic only eat food if other rats are eating it. Core mechanism determining energy balance trace to mutually antagonistic interactions arcuate nucleus: arc largely antagonistic to the pvn (paraventricular nucleus) Many arc systems innervate the pvn and vice versa. Core feeding circuitry and signals radiating from the interaction link to 2ndary downstream effects in the hypothalamus other brain regions behavioural/peripheral impacts. Lateral hypothalamus (lha) has hunger centre: lesion weight loss/anorexia; electrical stimulation elevated feeding, cells that express melanin-concentrating hormone (mch) and hypocretins/orexins 1 &
