BIOLOGY 1A03 Lecture Notes - Lecture 4: Kermode Bear, Metabolic Pathway, Byssus

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Lovaye Kajiura

Document Summary

Know components (structure/function/significance: enzymes, order **refer to diagram on in-class lecture. Delivery of charged trnas: elongation factors. Driven by gtp hydrolysis guanosine triphosphate. Genomic to proteomic complexity **refer to diagram in in-class lecture. Insulin processing; translated polypeptide coded in insulin gene is 110 a. a. long: functional insulin protein is made up of 2 chains: A-chain is 21 a. a, b-chain is 30 a. a. Formats of insulin: *refer to diagrams on in class lecture + in module: prepro insulin, proinsulin, functional insulin. Post-translational modifications: phosphorylation, methylation, acetylation, changes structure thus changes function. Should understand alternative splicing: consider primary transcript for a gene, which is spliced in different ways resulting in different mrnas which ultimately produces different polypeptides. Alternate receptors have different affinities to insulin **refer to diagram: depending on function. Should know how cells communicate w/ each other: cytoplasmic signalling proteins; insulin inducing uptake of glucose, effector organs.