BIOLOGY 1A03 Lecture Notes - Lecture 21: Genome-Wide Association Study, Glucose Tolerance Test, Diabetes Mellitus Type 2

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Alastair Tracey Rosa Da Silva

Document Summary

No effect on protein production or function. Noncoding snp changes in amount of protein produced. Coding snp changes amino acid sequence. Dna sequence variations in populations, where single nucleotide differs between different individuals or paired chromosomes. A-t and g-c matching with x and y alleles. Patterns are dependent on homozygosity or heterozygosity of alleles. Pattern of fluorescence of oligonucleotides depend on the number of snps found in genome. Snps occur more commonly in noncoding regions than in coding regions. Part of the team that published the first genome wide association studies (gwas) in complex diseases in 2007. Studies the genetic basis of obesity and type 2 diabetes. Published first family-based genome wide scan for childhood obesity, identified a significant region for linkage on chromosome 6q. Discovered a novel sim1 gene responsible for syndromic mendelian form of childhood obesity. Good predictor of future risk of type 2 diabetes. Identified that blood glucose level 1 hour after oral glucose tolerance test.