BIOLOGY 1A03 Lecture Notes - Lecture 2: Chromosome, Bronchus, Bronchoscopy

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BIOLOGY 1A03 Full Course Notes
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BIOLOGY 1A03 Full Course Notes
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Autosomal recessive manner > need a gene from mom and dad (2 gene copies to inherit it) Mucius buildup > pathogens dividing in moist envimt in lungs. Comes down to ion transport > inability to regulate properly > salty sweat! Normal to have transparent layer of mucous in airway. Bronchoscopy: to see whats present in trachea and bronchi. Molecular signal (something gone wrong in a gene) Cilia can only sweep back and forth in a non-viscous envmt. The whole pt of cilia is to capture bacteria etc and sweep them out or else lungs will be easily infected. Gene was localized and something in its blueprint was different > wrong transcription & translation > malfunctioning pritein. Mapped to chromosome 7 > cftr gene. Cftr protein main fn ability to transport chloride out of cell. In a normal airway, must be a balance between cl and na >> water gets regulated too.

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