BIOLOGY 1M03 Lecture Notes - Lecture 5: Human Leukocyte Antigen, Mns Antigen System, Genotype Frequency
15 Jan 2015
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Document Summary
Review of multiple choice questions from last class. Most human populations have two alleles for the mn blood group. How can we test if this locus is in hwe: estimate genotype frequencies by observation, calculate allele frequencies, use allele frequencies to calcite the expected genotypes frequencies assuming hwe, and, compare the observed and expected genotype frequencies. Since the genotypes at the mn locus are similar to hw expectations, we can conclude that the factors (selection, drift, migration, mutation, and biased mating) do not substantially a ect genotype frequencies of. This does not mean that mn blood types have always been in hwe. One generation of random mating can generate hwer genotypes for an autosomal locus (a gene not located on sex chromosomes) These data do not prove hwe but they do fail to reject the null hypothesis that the system is in hwe. Another point worth noting is that allele frequencies of di erent human populations are di erent.
