BIOLOGY 2B03 Lecture Notes - Lecture 2: Conformational Change, Scatter Plot, Fibril

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Prions: misfolded proteins, possibly secondary structure has been modified. You could have the appropriate sequence in genome and proper structure, but with misfolded protein, it"s induced. All proteins are linear polymers of amino acids. Condensation reactions polymerize amino acids releasing water. Hydrolysis breaks these polymers apart by adding water molecules. Secondary structure: conformation of a portion of the polypeptide. Tertiary structure: combination of the properties of the r-groups on the polypeptides. It"s the rough stable structure of a protein. The highest level of organization for a monomeric protein. Quaternary structure: number and organization of subunits in a multimeric protein. 4 domains, each monomer is its own tertiary structure. Pymol: databank of many primary structures around the world. Extracting that code results in you being able to create structures. Oxygen carrying protein in muscles, myoglobin, was the first protein to have 3d protein structure determined using x-ray diffraction crystallography: ball and stick model, ribbon diagram, space-filled model.

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