BIOLOGY 2B03 Lecture Notes - Lecture 6: Stat Protein, Sh2 Domain, Cytokine Receptor
23 Apr 2020
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Document Summary
Intracellular transduction: jak kinases and stat transcription factors: cellular response: transcription of stat target genes, inhibition of apoptosis. Receptor dimerization: epor has 3 domians: cytosolic domain, transmembrane domain and extracellular domain, each epor associated with jak kinase on its domain, dimerization of receptors by epo brings 2 jak kinases together so neighbor jak kinase is. Jak kinase unphosphorylated = inactive and weak kinase activity phosphorylated: known as autophosphorylation, jak kinase is a tyrosine kinase only tyrosine residues are phosphorylated. Dna and activate transcription: other domains, sh2 domains recognize phosphor-tyrosine, pdz domains recognize hydrophobic c-terminus. Target genes of stat: erythrogenesis associated with activation of stat5 transcription factor. Bcl-xl gene regulated by stat5 - bcl-xl protein an inhibitor of apoptosis: this allows differentiation into erythrocytes, mutations in genes coding for protein needed at different steps in cytokine pathway can cause same phenotype.
