BIOLOGY 2B03 Lecture Notes - Lecture 3: Unfolded Protein Response, Disulfide, Ern1

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30 Mar 2016
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Er"s are coninuous with the membrane of the nucleus. Membranes of the rer are constantly changing shape and structure (ission and fusion) and migraing to new locaions in the cell. Visualizing the rough er phase contrast used to see membranes of rer. Immuno- luorescence with green er speciic anibody we can see just rer membranes. Funcion of the rer site of co translaional transport, protein modiicaion, formaion of vesicles that will transport proteins from rer to golgi: ser. Funcion of the ser site of lipid (faty acids and phospholipids) synthesis, carbohydrate metabolism, calcium sequestraion to regulate calcium concentraion in the cytosol. Er lumen proteins - ptm"s can occur along the enire length of the protein. Er membrane proteins - ptm"s occur on the luminal side of protein: glycolsaion - covalent addiion of polysaccharides done to membrane proteins: proteins that mediate cell interacions and receptor ligand recogniion.

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