BIOLOGY 2C03 Lecture 7: Week 7 - Genetic Interactions

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Summary most phenotypes are determined by an interaction of many genes/env"t factors more than 2 alleles in pop. incomplete dominance and co-dominance of alleles two or more genes a ect one phenotype same gene produce variable phenotype: penetrance and expressivity. Case study - fur colour in cats multiple alleles contribute to fur colouration in cats. C > cb = cs >c > ca (in order of dominance) Loss of function allele: gene product not produced or not functional null/amorphic mutation = complete loss of gene function hylomorphic/leaky mutation = partial loss of gene function. Gain of function allele:gene product produced in excess or has new function hypermorphic and neomorphic alleles mutant allele may be more severe/lethal. Haplosu cient allele: one copy of the wild type makes enough functional protein to drive a reaction = complete dominance. Haploinsu cient allele: one copy of the wild-type allele does not make enough functional protein to drive a reaction.

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