BIOLOGY 2C03 Lecture Notes - Lecture 10: Intron, Voer, Reverse Transcriptase
23 Apr 2016
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Chromosome break point: location where dna has been severed. The broken ends retain their chromatin structure, and they can adhere to eachother or to other broken chromosome ends or to the ends of intact chromosomes. Acentric: parts of chromosomes without centromeres, will be lost during cell division. Large deletions are detected by microscopy by observing altered band patters. Genes will be affected and likelihood of large phenotype consequence is fairly high. Terminal deletion: a break that detaches one arm of a chromosome. This contains the chromosome ends (termini), consisting of a telomere and additional genetic material. Organisms containing one wt chromosome and one with a terminal deletion and called partial deletion heterozygotes. Interstitial deletion: loss of an internal segment of a chromosome that results from two chromosome breaks: eg. When cross over between homologs is inaccurate its results in mutations due to unequal crossover. The results of partial duplication and partial deletion of chromosome segments on the resulting recombinant chromosomes.
