BIOLOGY 2D03 Lecture Notes - Insulin Resistance, Thiolysis, Succinyl-Coa

42 views3 pages
28 Jan 2013
B-OH-Butyrate reduced to Acetoacetate (AcAc)
ratio determined by NADH/NAD in liver mito
**only in liver mito (where B-oxidation occurs**
some acetate decarbed to acetone
high fat (ketogenic) diet
prolonged exercise
diabetes (I)
fasting does not affect amt of glucose in blood
possible b/c alternate fuel utilization (80-fold inc in BHB)
changes during starvation
- brain shifts to ketone utilization to spare muscle
glucose still used, but not fully oxidized (to save it)
- LESS muscle breakdown
“sparing effect” due to ketogenesis
1) THIOLASE: 2 X AcetylCoA AcAcCoA + CoA (Thiolase INHIBITOR)
2) HMG-COA SYNTHASE: AcAc-CoA + acetyl-CoA HMG-CoA
(4C) (2C) (6C)
SH-CoA is lost from Acetyl CoA and INHIBITS SYNTHASE
2) HMG COA LYASE: HMG-CoA AcAc + AcetylCoA
(used in step 2)
Unlock document

This preview shows page 1 of the document.
Unlock all 3 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.