BIOLOGY 3UU3 Lecture Notes - Lecture 22: Neuropeptide Y, Leptin, Thermoregulation
4 Apr 2016
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Relaionship between body mass and rate of proton leak. Proton leak is greater for small animals mitochondria are less eicient (generate more heat) Part of the relecion of changes in sa:volume raio fundamental molecular level alteraion. No brown adipose issue, creaing heat (proton leak, uncoupling) Paradigm used as teh main model to look at aging rates. Restrict calories and resources to 60% of normal, maintaining minerals and vitamins (caloric restricion) get a smaller animal that matures later and has slower aging rates (orexins upregulated) Gh axis and simulaion of tor these mice have a reducion in tor and an increase in foxo (change the aging rates) Extended longevity not due to changes in metabolic rates. Life extension is a diference between 32-44 months (large diference) Looking at orexins afect on fat thermogenesis is controversial they increase temperature and foraging, but they don"t uncouple protein 1 in brown fat. Uncouple protein 3 in muscle (makes sense for foraging)
