BIOLOGY 4X03 Lecture Notes - Lecture 11: Skeletal Muscle, Cytochrome C, Malic Acid
8 Nov 2016
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Skeletal muscle: each fascicle is made p of myofibres which are in turn made up of myofilaments, atp is required for cross bridge cycling, 2 types of mitochondria. Subsarcolemmal: closer to the peripheral of the cell; closer to the capillaries. Intramyofibril: in the center space of the cell. Best way to counteract hypoxia is to increase aerobic capacity of the muscle: as hypoxia increases muscle oxygen consumption rate increases as well, to increase aerobic capacity we can increase the number of mitochondria. Another way to increase aerobic capacity is to increase the respiratory capacity of mitochondria: etc. Electrons are passed through out the complexes and protons are pumped into the cytoplasm. This generates the required energy to produce atp: respiration comes from complex 4 since it is the only one that consumes oxygen, however we can stimulate or inhibit certain complexes with accessory molecules. Glutamate or pyruvate and malate activate complex 1.
