HTHSCI 1DT3 Lecture Notes - Lecture 7: Collagen, Eosinophilia, Asthma
13 Aug 2020
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Mod. 3 tutorial - the riddle of house dust mite 1. They could synergize in inducing asthma exacerbations: beas-2b cells were exposed to activated hdm major allergen (der p1), hrv (1b or 16) or to both in difference sequences. Il-8 release, icam-1 surface expression and nuclear factor kb translocation were evaluated: rv and der p1 upregulated il-8 release, icam-1 expression and nf-kb translocation. Concurrent exposure induced an early synergistic nf-kb translation induction, differentiating with time, partly explaining the above observation: describe the models system(s) and experimental plan. However, der p1 action is short lived, showing effects during the first hours of exposure (2 hours) Hrv, transcriptional activation depends to a large extent on replication and takes more time (24 hours) Mod. 3 tutorial - the riddle of house dust mite 2. Csf, il-25 and il-33: absence of tlr4 on structural cells abolishes hdm-driven allergic airway inflammation.
