HTHSCI 1DT3 Lecture Notes - Lecture 23: Monocyte, Interleukin 13, Signal Transduction
13 Aug 2020
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Mod. 2-5 cytokines, chemokines and their receptors 3. Chemokines: definition: as above, chemokines fall into 4 sub-families based on positioning of critical cysteine residues. This shows a change of protein signalling to lipid signalling: while dag activates pkc, ip3 binds to receptor on er, allowing ca2+ ions to leave er. There are a few types of t cells (th1, th2, th17 and treg). In copd patients, there are high levels of cd8+ t cells at the sites of obstruction (small airways) and these t cells express cxcr3 and ccr5. Cxcr3 is also found in monocytes, b cells, nk cells and macrophages. With high levels of chemokines in copd acting on cxcr3 and ccr5, there is higher chemotaxis of cd8+ t cells. Hence, targeting cxcr3 and ccr5 can possibly block the effects of these chemokines and then the chemotaxis of cd8+ t cells. Mod. 2-5 cytokines, chemokines and their receptors 4.
