HTHSCI 1DT3 Lecture Notes - Lecture 11: Interleukin 8, Interleukin 5, Chromatin
13 Aug 2020
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Mod. 2-11 epigenetics, inflammation and airways disease 2. Ting joe li yah: covalent histone modifications, acetylation gene activation, methylation gene activation/repression. Methylation of lysine 4 on histone h3 (h3k4me3) activates transcriptional promoters. Methylation of lysine 9 & 27 on histone h3 represses transcription promoters, and these two modifications constitutes the main silencing mechanisms in cells: phosphorylation and ubiquination, there is cross-talk between dna methylation and histone modifications histone. When placed in medium with the presence of il-2, il-4, il-5 and il-13, na ve t cells will become th2 cells. When placed in medium with the presence of il-2, il-12 and ifn , na ve t cells will become th1 cells. Repressive marks are seen on certain genes: enzymes involved in changing gene expression, histone acetyltransferase (hat) transcription activators, histone deacetylase (hdac) gene silencing, reverse acetylation and change structure of. Class i, ii and iv are inhibited by trichostatin a (tsa) (non-specific)
