HTHSCI 1DT3 Lecture Notes - Lecture 14: Mast Cell, Gene Expression, Isothiocyanate
13 Aug 2020
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Mod. 2-17 nervous system of the airways 2. Ting joe li yah: neurotransmitters, vasoactive intestinal peptide (vip), a peptide hormone and its effect on the airways. Vip causes bronchodilation of airway and could cause relaxation of airway smooth muscle cells by preventing the release of ach (which will act on m3) However, tryptase produced by mast cells can destroy vip: role for no in inhibitory nonadrenergic noncholinergic (inanc) relaxation of trachea. This is shown by nos inhibitor, l-name, which significantly reduces maximum relaxation: airway sensory nerves, mechanosensors: rapidly adapting receptors (rars) Generally not do not respond directly to chemical stimuli. Presumed to be the primary afferent nerve fibres that evoke defensive cough. Activated by airway smooth muscle constriction, mucous accumulation, mechanical irritation and even hypertonic, capsaicin and bradykinin application: chemosensors: c-fibres and a nociceptors (cid:198) chemosensors. Activated directly by a wide range of chemicals, including capsaicin, bradykinin, adenosine, pge2 and low ph. Extrapulmonary low threshold mechanosensor but functionally different from rars.
