HTHSCI 1DT3 Lecture Notes - Lecture 8: Shortness Of Breath, Viral Disease, Clinical Trial
13 Aug 2020
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Mod. 1-17 pathobiology of novel treatments for idiopathic pulmonary fibrosis 2. Upon exposure to infectious agents, the immune response will be triggered to clear the antigens but then persist. This can cause scarring: lofgren"s syndrome, the enlargement of lymph nodes near the inner border of the lungs and can be picked up through chest x-ray. It may be accompanied by arthritis and fever: treatment: corticosteroid therapy, get rid of the granuloma (the symptoms), but not cure it, some patient will get better without treatment, while others may progress to chronic disease. However, it is not possible to differentiate these two types of patients: 2nd line agents such as azathioprine and cyclophosphamide are used if there is fibrosis or cardiac involvement. Treatment is more important to prevent disease progression: 3rd line agents such as thalidomide and doxycycline. Steroid make them better but does not change the outcome. Once recover, lung function goes back to normal: chronic: there is airway granulomas and fibrosis.
