HTHSCI 1DT3 Lecture 8: anatomy sur-58-65

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Piling up of goblet cells and absorptive cells. Tumour-like growths composed of tissues present at site where they develop. May have blood / mucus pr, tenesmus. Crc risk: need surveillance and polypectomy. May be assoc. c congenital hypertrophy of the retinal pigment epithelium (chpre) Attenuated fap: <100 adenomas, later crc (>50yrs) Osteomas of the mandible, skull and long bones. Remain @ risk of ca in stomach and duodenum. Commonest cause of hereditary crc: 3% of all crc. Lynch 2: crc + gastric, endometrial, prostate, breast. 3 family members over 2 generations c one <50yrs. Acute severe abdominal pain pr bleed. Cause: atheroma + low flow state (e. g. lvf) Cause: follows low flow in ima territory. Large upper gi bleed (15% of lower gi bleeds) Bloods: fbc, u+e, lft, x-match, clotting, amylase. Angiography: necessary if no source on endoscopy. Abx: if evidence of sepsis or perf. Keep bed bound: need to pass stool may be large bleed.

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