HTHSCI 1DT3 Lecture Notes - Lecture 14: Critical Limb Ischemia, Precancerous Condition, Sympathectomy
26 Dec 2020
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Commonest cause of cancer death in females 15-54. Second commonest cause of cancer deaths overall. One 1st degree relative = 2x risk. Brca1 (17q) 80% breast ca, 40% + ov ca. Lymph p"eau d"orange + arm oedema. Cystic lump: fnac (green / 18g needle) Breast mri: multifocal disease or c implants. Stage 1: confined to breast, mobile, no lns. Stage 2: stage 1 + nodes in ipsilateral axilla. Stage 3: stage 2 + fixation to muscle (not chest wall) Stage 4: complete fixation to chest wall + mets. T4: >10cm, chest wall extension, skin involved. Manage in an mdt c an individual approach. Try to enrol pts. in a trial. Wle + radiotherapy (80% treated like this) Same survival, but wle has recurrence rates. Sn = first node that a section of breast drains to. If clinically ve axillary lns, no need for further dissection if sn is clear. Blue dye / radiocolloid injected into tumour.
