HTHSCI 1H06 B Lecture Notes - Lecture 9: Ige, Natural Killer Cell, Apoptosis
22 Jun 2018
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ADAPTIVE IMMUNTIY
DD
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Innate vs Adaptive Immunity :Relative Importance Immunological Memory
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Innate is more important than adaptive
←lacking innate
§LARGER
±t
be §
FASTER
Duration of Importance t
Transition from Innate to Adaptive responses
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lag phase is then because you need hme for antigen presenting cells Aturn on
adaptive Immune response
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Antigen presenting cell : specialized phagocyte Idendritic ,macrophage ,
1cell )that
in Hratt with aTcell that is specific for specific antigen
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dendritic all ,macrophage or 13 cell picks up pathogen and shows it to tell
What Is an antigen ?
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Amgen :any molecule that an antibody can specifically bind to
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Name comes from ability to generate antibodies ly -domain +variable region )
>
proteins
>
Carbs
>
Nucleic acids
Antibody
•ldett an effect rmolecule produced by Bcells that is specific for agiven antigen
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When antibody binds to its ahhgen ,It tags the pathogen for destruction by phagocytes
Imacrophages +neutrons )
Antigen Presentation
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Tcells cant recognize
"native "anhgeh -
only processed fragments of antigen 1peptides )
•APCS pick up antigen ,process it ,and presents It to Tcells on Major Into compatibility Complex IMHC)PNHIH
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MHC 's discovered through tallied tissue transplantation operations
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MHCI is expressed on all nucleated cells ,while MHUI is only expressed on pwksslonal APG
nhqeh Processing
•Intracellular pathogens (virus )→makes proteins
using
our machinery +proteins are loaded Into MHCI and are pretend on the surface
-MHCI presents antigens to a) 8+1141 Hrtlell )
•Extracellular pathogens 1bacterial →anhaen it taken into vehicle + we load it into MHCH and Its put onto the surface
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MHLH PHHHH antigen to 4) 41 helper TUH )
