HTHSCI 1H06 Lecture Notes - Lecture 20: Phosphocreatine, Water Intoxication, Furosemide
27 Jul 2018
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If there"s too much water or too few ions in the body, dilute urine must be made to re- establish balance. If you have too much dilute blood then you will have water intoxication and may die (about 6 l in less than 3 hours would do it) This urine has to be more dilute in ions than blood so it has to be less than 300 mosm/l. Next figure illustrates the formation of dilute urine using a short loop nephron. The tubules emphasized with brown are always largely impermeable to water. The collecting ducts (lined with blue) are largely permeable to water in the presence of antidiuretic hormone (adh) In the pct, solutes are reabsorbed and water follows them out of the tubule: filtrate enters descending loh. The loss of water makes the filtrate more concentrated and osmolarity goes up: the filtrate enters the thick ascending limb of the.
