HTHSCI 1H06 Lecture 5: Lecture 5 Summary Notes
11 Jan 2019
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Modern receptor theory: in the clark model, molecules jostle one another fro a receptor; addition of ligand causes saturation which allows for the maximum effect to occur. So, at any given time, some receptors are. Active without the ligand (able to produce transduction effects): the ligand is attracted to these active receptors and binds to them, shifting the equilibrium of active/inactive receptors. In accordance with le chatelier"s principle, a greater number of inactive receptors become activated and continue to attract ligand to compensate: the equilibrium continues to shift towards the dr complex. Think of it like a cafeteria: at any time, there will be a few slices of pizza out. Because histamine in some parts of the brain allows us to stay awake, decreased levels can lead to sleepiness or even narcolepsy. This is pharmacological antagonism: reversible/surmountable/competitive: will change potency, not efficacy.
