HTHSCI 1H06 Lecture Notes - Lecture 24: Sodium Bicarbonate, Opiate, Haco
8 Jan 2015
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Sustained levels outside of that range are indicative of pathology. Below 7. 35 is called physiological acidosis: we cannot survive long excursions from the normal ph range. Alkalosis is a much more rare problem and is almost never fatal. Acidosis is a serious problem and can be fatal, at a ph of about 7. 0 the cns becomes so depressed normal functioning ceases: how we manage to avoid the extremes of ph buffers! For buffers one of the reactants is h+ thus the buffer systems act to keep h+ in balance. The buffer consumes h+ so if h+ increase the buffer will consume it. If h+ decreases the buffer will produce h+: ultimately a buffer system can be completely consumed by attempting to balance large changes in h+ Can be used up: there are both intracellular and extracellular buffers. In the urine we have both the phosphate buffer system and the bicarbonate buffer system playing a role.
