HTHSCI 1H06 Lecture Notes - Lecture 1: Ichthyosis Vulgaris, Stratum Spinosum, Stratum Basale
19 Mar 2016
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Document Summary
Responsible for the vital barrier function of the skin. Key to healthy skin and its associated attractive appearance. Three to five layers of keratinocytes make up this layer. Keratinocytes migrating from the underlying stratum spinosum become known as. 3-5 layers of cells granular cells in this layer. Keratohyalin granules are found to be decreased in number in people who have disease known as ichthyosis vulgaris, where the skin becomes dry and scaly. Protein called filaggrin is manufactured by the cells of the granular layer and is normally the main substance found inside keratohyalin granules. Filaggrin is thought to play an important part in the structure of the outer layer of the skin, and also helps it to retain moisture. Ichthyosis vulgaris may be treated by hydrating the skin and adding an ointment on top to stop moisture escaping. Spiny appearance s due to the shrinking of the microfilaments between desmosomal that occurs when stained with h&e.
