HTHSCI 1LL3 Lecture Notes - Lecture 15: Autoimmune Disease, Hyperglycemia, Low-Density Lipoprotein
22 Jun 2018
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Department
Course
Professor
LIPIDS
DDSS
Overview
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ban begin in mouth + stomach with lingual +gastric
lipase Iyoung children need this for fat In milk )
•Most of digestion happens in small intestine
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Triglycerides →
monoglycen
'de + FA → absorbed
Into en Hwcytes →(hyl omicron →lacteal →
blood stream via thoracic duct (lymph )
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LPL :takes FA out to be taken up into
adipose tissue Istorage )+muscle lfnen
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can store asmall amount of glycogen in muscle
or liver ,unlimited fat ,but cant store protein
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Excess protein +carbs need to be turned into
fat to be stored
Triglycerides
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1deft major dietary source of fat ;glycerol wl 3tatty acids
•hydrolyzed to FAS and 2monoacyl glycerol in small Intestine
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Long chain →Put Into chylo microns became they 're insoluble jShort + Medium chain →soluble .
'
.can enter +join albumin
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lingual tgastric lipases are most active with short +medium chain 1type found In milk .
'
.young children )
Bile salts
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Triglycerides arent soluble In the aqueous environment of the intestine Ior blood )
•Bile salts :derivative of cholesterol made by liver ,act as
"
emulsifiers
"
to surround the fats +break them down + absorbed
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Secreted by gallbladder lwl phospholipids )where they restored
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amphipathic :hydrophobic on inside thydrophilic on outside
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C011 pale binds to the fat + bile JAHJ around droplets So lipase can breakdown the tas into FA + munoglycerides
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When bile reaches concentration >critical micelle concentration ,
micelles form
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Fat soluble vitamins +cholesterol are packaged in micelles wl TGS to be absorbed through micwvilli of Intestine
Micelles
•(def .)polar heaaj around outside surrounding hydrophobic materials within
•bite salts are released from gall bladder +enzymes from pancreasedue to choleoystoklnin
when chyme enters duodenum (bicavb also reheated due to signal from Korean to
neutralize pH t allow enzymes to function )
Document Summary
Overview ban begin in mouth stomach with lingual. + gastric lipase i young children need this for fat. Into en hwcytes ( hyl omicron lacteal blood stream via thoracic duct ( lymph ) Fa out to be taken up into adipose tissue. I storage ) muscle lfnen can store a small amount of glycogen in muscle liver unlimited fat , but cant store protein or. Excess protein + fat to be stored carbs need to be turned into. Into chylo microns became they "re insoluble j short. + join albumin lingual t gastric lipases are most active with short + medium chain. Bile salts : derivative of cholesterol made by liver act as emulsifiers to surround the fats break them down absorbed. Secreted by gallbladder lwl phospholipids ) where they restored amphipathic : hydrophobic on inside t hydrophilic on outside. When bile reaches concentration critical micelle concentration micelles form.
