HTHSCI 1LL3 Lecture Notes - Lecture 16: Kwashiorkor, Phenylalanine, Anticoagulant
22 Jun 2018
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PROTEINS
Do §
overview
•starts in stomach where there is Hu release +pepsinogen release
Iturns into pepsin )
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pepsin
:cuts down proteins
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Proteins :long polymers of AAs
>When broken down called peptides
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Peptides enter small intestine and signal →Pancreas to send In dlgelhh
enzymes +bicarb
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Trypsinogen ,chymotrypsinoqen ,
proelastase
,pro carboxypeptiaase
←zymogens packaged in Panchal In inactive form
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Enzymes get activated +aminopeptidase in brush border break down
diltri peptides
Protein Digestion
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begins in stomach
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Hu is released by gastric parietal cells denatures proteins to make it easier for pepsin to cleave
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Pepsi hogen Isecreted by Chief cells ):zymogeh form of pepsin
-Hu allows conversion to pepsin
Digestive Enzymes
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Release of Hu allows qepsmogen to auto cleave
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ENHWPEPH date : in brush border so when panchal releases Inactive photolytic enzymes trypslnogeh →
trypan
pH for Enzyme Function
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pH for proper functioning of pepsin ogen in stomach
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pH =1.5 -2
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why else do we need at pH in stomach
→probation breaks bonds
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denamration for cleavage allowing pepsin access to cleave
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PH in intestine for proper Mhltioning of other digestive enzymes
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pH =6
•• How do we change this PH
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bicarbonate from pancreas
•what can Hrelease of the agent that adjusts pH
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Ubkt HCHHH tell pancreas to secrete enzymes +bicdrb Into stomach
Pancreatic Enzymes
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Once food leaves stomach ,pancreas releases enzymes +bicarb to neutralize chyme to allow enzymes to function
•Pancreatic protease an Healed as zymogens so they dont digest each other
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Trypnn cleaves the other zymogens to activate them In lnleltme ,nhen they break proteins down to di +tri peptides
Document Summary
Proteins overview starts in stomach where there is hu release pepsinogen release. Proteins : down proteins long polymers of aas. Pancreas to send in dlgelhh enzymes bicarb. Enzymes get proelastase diltri peptides aminopeptidase activated border break brush down in. Hu is released by gastric parietal cells denatures proteins to make it easier for pepsin to cleave. Pepsi hogen i secreted by chief cells ) : zymogeh form of pepsin. Release of hu allows qepsmogen to auto cleave. Enhwpeph date : in brush border so when ph for enzyme function panchal releases. Inactive photolytic enzymes trypslnogeh trypan ph for proper functioning of pepsin ogen in stomach. = 1. 5 - 2 ph why else do we need at ph in stomach denamration for cleavage probation allowing breaks bonds pepsin access to cleave. Ph in intestine for proper mhltioning of other digestive enzymes ph =6.
