HTHSCI 1LL3 Lecture Notes - Lecture 18: Inner Membrane, Main Source, Cellular Respiration
22 Jun 2018
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Professor
TCA CYCLE AND ETC
¢¢¢
.
DCC
ATP =Energy Currency
yttiothbtonds
•
ATP is in RNA Ionly one PIn RNAI
•Phosphates are negative +high energy bonds hold them together
•
Biosynthesis :process of making proteins ve need
•
Detoxification →urea cycle
•
Importance of ATP :if heart (ant make Atp ,
all Its ATP Would t supply and demand
run out in <1mm
Heat
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each heartbeat uses 2% of hearts ATP ^
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heart must use oxidative phosphorylation to produce ¥|
enough ATP
,
which is why lack of oxygen due to ablockage
in coronary artery Is so problematic Carbs Muscle contraction
•
Much less ATP is made by anaerobic glycol ysis Iin cytosol )4Pa Active ion transport
protein Biosynthesis
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tissue Ihltht oxygen or no mitochondria IRB c) must use this /Dehxitcahon
02 Thermo genesis
method of energy generation
Glucose
-
hypoxic tissues use this pathway at hell ,
over the short term
NADH #ATP
until oxygen delivery is restored ,which is why lactate In the blood §pyruvate
4uted as an indicator of tissue perfusion Y\
Lactate
kNADAL '
Acetyl CoA
Fuel oxidation anagrams ¥gy
.
ftettntfhfcnnhonaaeia
and oxygen
•All of the different macronutrients can be metabolized to acetyl CoA
•
Acetyl COA is the substrate for the trr carboxylic acid cycle (TCAI
-
2Cmolecule that everything has to turn into to enter the TCA to generate
energy aerobically
Energy Metabolism
•
2phases
'Oxidation of fuels to get them into Acetyl -CoA
2ATP generation from oxidative phosphorylation Hypoxia
t mitochondrial
Oxygen Requirement Etc
•
Need oxygen to efficiently provide energy tATP + adenine
•nucleotides t.ca "
Anything that interferes with 02 delivery threatens life
•4Nat
Issue hypoxia results in cell death ,anoxia It 02 )
,chemicals llyahide )can block 02 usaae ,no energy mitochondria ,
permeability
generation swelling transition
pore
in plasma membrane tprogram !cell
pevmeabilltb death
Document Summary
Biosynthesis : process of making proteins ve need. Atp would t supply and demand run out in. Atp heart must use oxidative phosphorylation to produce enough atp which is why lack of oxygen due to a blockage in coronary artery is so problematic. Much less atp is made by anaerobic glycol ysis. I in cytosol ) tissue i hltht oxygen or no mitochondria. Irb c) must use this method of energy generation hypoxic tissues use this pathway at hell over the short term until oxygen delivery is restored. 4 uted as an indicator of tissue perfusion. All of the different macronutrients can be metabolized to acetyl coa. Acetyl coa is the substrate for the trr carboxylic acid cycle ( tcai. 2 c molecule that energy aerobically everything has to turn into to enter the. It 02 ) chemicals llyahide ) can block 02 usaae no energy generation. 4 nat swelling mitochondria permeability transition in plasma membrane t pevmeabilltb pore program.
