HTHSCI 2C06 Lecture Notes - Lecture 3: Blunt Trauma, Thromboxane A2, Nitric Oxide
21 Mar 2016
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Acute inlammaion cellular injury or pathogenic invasion: mast cell release of chemical mediators: histamine (bronchoconstricion, vasodilaion), bradykinin, complement, leukrotrienes, ****redness, swelling (this is part of healing; not a bad. Thing****) vasodilaion vascular permeability (edema) cellular iniltraion (pus) thrombosis (clots) Get swollen, increase permeability for plasma proteins to come to the area . : causes of inflammation: burns, blunt force trauma, infecion, extreme temperatures cold hands then you bring them inside quickly (and it burns and. Hurts), extreme heat (at extreme temperatures it causes cellular injury) Hospital intake paients increase in wbc = this arises simply from the stress response. Nitric oxide, atp) or constrict (thromboxane a2, endothelin-1, ace) If more o2 needed then vasodilate, if plenty of o2 or damage (limit area inlow) then vasoconstrict: cell traicking. Icam (intracellular adhesion molecules sends signals to express adhesion molecules to the surface), vcam, - adhesion molecules: coagulaion. Communication b/w cells: pro-inlammaion tnfa, il1, il2, ani-inlammaion il4, il10, il13.
